1目的　探讨人宫颈癌 P5 3基因突变与临床病理特征的关系。 2方法　采用聚合酶链反应 (PCR)和限制性酶切片断长度多态性分析 (RFL P)技术 ,检测 34例宫颈癌第 6 ,7外显子的突变。 3结果　检出突变 6例 ,突变与临床分期、病理学分级有关 ,而与年龄、组织学类型无关。 4结论　 P5 3基因突变是宫颈癌发生的原因之一。 1 Objective To investigate the relationship between the mutation of P53 gene and clinicopathological features in human cervical cancer. 2 Methods Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) were used to detect the mutations of exon 6 and 7 of 34 cervical cancer patients. 3 results detected mutations in 6 cases, the mutation and clinical stage, pathological grade related, but not with age, histological type. 4 Conclusion P5 3 gene mutation is one of the causes of cervical cancer.