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目的探讨血清胆红素水平与高尿酸血症的关系,进一步认识高尿酸血症患者的临床特点。方法回顾性分析参加体检的4 812例研究对象的临床资料,分析血清胆红素水平与高尿酸血症的相关关系。结果高尿酸血症患者组血清总胆红素(TBil)水平显著高于正常对照组[13.0(10.0~16.0)μmol/L.vs 12.0(9.0~15.0)μmol/L,P<0.05],且随着血清TBil水平升高,高尿酸血症患病率逐渐上升;相关性分析发现血清TBil水平与BMI、腰围、LDL-C、空腹血糖、肌酐均呈正相关(均P<0.05);进一步多因素logistic回归分析发现,血清TBil水平是高尿酸血症的患病危险因素[OR(95%CI)=1.021(1.007~1.034),P<0.05]。结论血清胆红素水平变化与高尿酸血症存在密切联系,高尿酸血症患者血清胆红素水平显著升高。
Objective To explore the relationship between serum bilirubin level and hyperuricemia and to further understand the clinical features of patients with hyperuricemia. Methods The clinical data of 4812 subjects participating in physical examination were retrospectively analyzed. The correlation between serum bilirubin level and hyperuricemia was analyzed. Results The level of serum total bilirubin (TBil) in patients with hyperuricemia was significantly higher than that in the control group [13.0 (10.0-16.0) μmol / L. vs 12.0 (9.0-15.0 μmol / L, P <0.05] The prevalence of hyperuricemia gradually increased with the increase of serum TBil level. Correlation analysis showed that serum TBil levels were positively correlated with BMI, waist circumference, LDL-C, fasting blood glucose and creatinine (all P <0.05) Logistic regression analysis showed that serum TBil level was the risk factor of hyperuricemia [OR (95% CI) = 1.021 (1.007-1.034), P <0.05]. Conclusion Serum bilirubin levels are closely associated with hyperuricemia, and serum bilirubin levels are significantly elevated in patients with hyperuricemia.