论文部分内容阅读
近年来细菌对β-内酰胺类抗生素的耐药性研究从外膜通透性减少、β-内酰胺酶的水解作用和青霉素结合蛋白的改变三方面着手进行。外膜上的Porin通道是影响药物渗透的关键因素。β-内酰胺酶的水解作用则是引起细菌耐药性的重要原因,而非水解屏障和缓慢水解学说补充解释了耐药机制的复杂性。PBPs的改变不含β-内酰胺酶耐约菌的普遍特点,缓慢结合的PBPs或诱导产生的PBPs也与耐药性密切相关。本文阐明了三者间的关系及克服耐药性的有效方法。
In recent years, bacterial resistance to β-lactam antibiotics has been studied in three aspects: reduction of permeability of the outer membrane, hydrolysis of β-lactamase and alteration of penicillin-binding protein. The Porin channel on the adventitia is a key factor affecting drug penetration. The hydrolysis of β-lactamase is a major cause of bacterial resistance, whereas the non-hydrolytic barrier and slow hydrolysis supplement explain the complexity of the mechanism of resistance. Changes in PBPs do not include the common features of beta-lactamase-resistant bacteria. Slowly bound PBPs or induced PBPs are also closely linked to drug resistance. This article clarifies the relationship between the three and an effective way to overcome resistance.