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[目的]评价美托洛尔、苯那普利和硝酸甘油联用治疗慢性心力衰竭的疗效。[方法]63例慢性充血性心力衰竭患者随机分为对照组30例,联合用药组33例;对照组予苯那普利、利尿剂、硝酸甘油、洋地黄等常规治疗。联合用药组在上述治疗基础上加服美托洛尔,疗程均为1个月。[结果]联合用药组与对照组的心率、收缩压和舒张压与治疗前相比,均有所降低,差异有统计学意义(P﹤0.05),而联合用药组降低的程度大于对照组;联合用药组有效率为90.9%(14例显效,16例有效,3例无效;对照组总有效率为73.3%(9例显效,13例有效,8例无效);两组总有效率比差异有统计学意义(P﹤0.05),两组均无严重不良反应。[结论]苯那普利治联合小剂量美托洛尔治疗慢性心力衰竭疗效优于单用苯那普利,且不良反应少,值得推广应用。
[Objective] To evaluate the efficacy of metoprolol, benazepril and nitroglycerin in the treatment of chronic heart failure. [Method] 63 patients with chronic congestive heart failure were randomly divided into control group (n = 30) and combination group (n = 33). The control group was given benazepril, diuretic, nitroglycerin and digitalis. Combined treatment group on the basis of the above-mentioned treatment plus metoprolol, treatment were 1 month. [Results] The heart rate, systolic blood pressure and diastolic blood pressure of the combination group and the control group were significantly lower than those before treatment (P <0.05), but the combination group decreased more than the control group. The effective rate was 90.9% in combination group (14 cases markedly effective, 16 cases effective, 3 ineffective; control group, the total effective rate was 73.3% (9 cases markedly effective, 13 cases effective, 8 cases ineffective); total effective rate difference between the two groups (P <0.05), and no adverse reactions were observed in both groups. [Conclusion] Benazapril combined with low-dose metoprolol in the treatment of chronic heart failure is superior to benazepril alone in the treatment of chronic heart failure with less adverse reactions , It is worth promoting application.