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目的观察山莨菪碱(654-2)减少阿奇霉素副作用的效果。方法对108例肺炎患儿随机分为两组,观察组56例,用654-2注射液与阿奇霉素注射液混于同一瓶液体中静滴;对照组52例,单有阿奇霉素静滴,观察两组主要副作用(包括恶心、呕吐、腹痛)的发生率。结果观察组副作用发生率低于对照组,肺部啰音消失快、住院天数短,差异均有显著性意义。结论654-2能减少阿奇霉素的副作用,且能促进肺部病变痊愈,值得儿科临床应用。
Objective To observe the effect of anisodamine (654-2) on reducing side effects of azithromycin. Methods 108 cases of children with pneumonia were randomly divided into two groups, the observation group of 56 cases, with 654-2 injection and azithromycin injection mixed with the same bottle of liquid intravenous infusion; control group of 52 patients with only azithromycin intravenous infusion observed two The incidence of major side effects (including nausea, vomiting, abdominal pain) in the group. Results The incidence of side effects in the observation group was lower than that in the control group, the pulmonary rales disappeared quickly, the days of hospitalization were short, the differences were significant. Conclusion 654-2 can reduce the side effects of azithromycin, and can promote the recovery of lung disease, it is worth pediatric clinical application.