目的　探讨醋酸甲孕酮对作业工人健康的影响。方法　对观察组和对照组按统一要求询问职业接触史、疾病史、家属史等 ,以及较全面的体格检查 ,同时进行血液流变学、凝血酶原时间、谷丙转氨酶等及B超肝脏声像图的观察。结果　观察组血液流变异常、凝血酶原时间缩短发生率与对照组比较有极显著差异 (P <0 .0 1) ;观察组B超声像显示肝脏光点增粗发生率与对照组比较有显著性差异 (P <0 .0 5 )。结论　高浓度醋酸甲孕酮对作业工人血液流变、凝血功能及肝脏有一定损伤作用。 Objective To investigate the effects of medroxyprogesterone acetate on the health of workers. Methods The observation group and the control group were asked about the occupational exposure history, disease history, family history and so on, as well as a more comprehensive physical examination. At the same time, hemorheology, prothrombin time, alanine aminotransferase, Like the observation of the figure. Results The observation group had abnormal hemorheology and shortened prothrombin time compared with the control group (P <0.01). The ultrasonography of the observation group showed that the incidence of hepatic spot thickening was significantly higher than that of the control group Significant difference (P <0. 05). Conclusion High concentration of medroxyprogesterone acetate has some effects on blood rheology, blood coagulation and liver in workers.