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目的探讨抗生素所致药物热的特点、诊断及治疗方法。方法回顾性分析32例明确诊断的抗生素致药物热的临床资料。结果原发病有发热者用药后体温较前更高,达38.5～40.2℃,原发病无发热者用药后体温在37.6～38.5℃,热型不固定,其中弛张热13例(40.62%),稽留热10例(31.25%),不规则热6例(18.75%),另有4例因为使用解热镇痛药物故热型无法统计。停用药物后多数患者24～48 h体温恢复正常,5例(15.62%)出现皮疹。辅助检查:白细胞增高8例(25.00%),嗜酸性粒细胞比例增高14例(43.75%)。停用可疑致药物热的药物后患者体温恢复正常。结论药物热的发生与变态反应有关,临床医生应合理用药。
Objective To investigate the characteristics of antibiotics-induced drug fever, diagnosis and treatment. Methods Retrospective analysis of 32 cases of clinically diagnosed antibiotics induced drug fever clinical data. Results The incidence of fever in patients with primary disease after treatment was higher than the previous temperature, up to 38.5 ~ 40.2 ℃, the primary disease without fever in patients with body temperature 37.6 ~ 38.5 ℃, heat type is not fixed, including 13 cases of fever (40.62% ), Missed the heat in 10 cases (31.25%), irregular heat in 6 cases (18.75%), and the other 4 cases because of the use of antipyretic analgesics so the heat can not be counted. Most patients after discontinuation of the drug returned to normal temperature in 24-48 h, and rash appeared in 5 cases (15.62%). Auxiliary examination: leukocytosis in 8 cases (25.00%), eosinophils increased in 14 cases (43.75%). The patient’s body temperature returned to normal after cessation of suspected hot drugs. Conclusions The occurrence of drug fever is related to allergic reaction, and clinicians should take reasonable medication.