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目的:观察比较阿托伐他汀与辛伐他汀临床调指疗效及安全性。方法:将160例高脂血症患者随机分成两组。A组:阿托伐他汀10mg/d;B组:辛伐他汀10mg/d。治疗前、治疗后4周、8周化验血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、甘油三脂(TG)、谷丙转氨酶(SGPT)、肌酸激酶(CK)。结果:阿托代他汀及辛伐他汀均能明显降低TC(P<0.05)、LDL-C水平(P<0.01),阿托伐他汀降LDL-C作用强于辛伐他汀(P<0.05),阿托伐他汀能明显降低TG水平(P<0.05)辛伐他汀8周后降TG水平达到显著差异(P<0.05),阿托代他汀降TG作用明显强于辛伐他汀(P<0.05),两药均能升高HDL-C水平(P<0.05),但两组间比较未达到显著差别(P>0.05)。两药均有良好安全性。结论:阿托伐他汀、辛伐他汀均能明显降低TC、LDL-C、TG水平,阿托代他汀降LDL-C、TG作用优于辛伐他汀,两药均能升高HDL-C水平。
Objective: To observe and compare atorvastatin and simvastatin clinical indexing efficacy and safety. Methods: 160 cases of hyperlipidemia were randomly divided into two groups. Group A: Atorvastatin 10mg / d; Group B: Simvastatin 10mg / d. The levels of total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), triglyceride (TG), alanine aminotransferase (SGPT), creatine kinase (CK). Atorvastatin and simvastatin significantly reduced TC (P <0.05) and LDL-C levels (P <0.01), and atorvastatin reduced LDL-C more significantly than simvastatin (P <0.05) Atorvastatin could significantly reduce the level of TG (P <0.05), and after 8 weeks of simvastatin, the level of TG decreased significantly (P <0.05), the effect of atorvastatin on TG decreased significantly (P <0.05) ), Both drugs can increase HDL-C levels (P <0.05), but the two groups did not reach a significant difference (P> 0.05). Both drugs have good safety. Conclusion: Both atorvastatin and simvastatin can significantly reduce the levels of TC, LDL-C and TG, atorvastatin reduces LDL-C, TG is better than simvastatin, and both drugs can increase the level of HDL-C .