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S100B蛋白主要由星形神经胶质细胞分泌,生理浓度下具有神经营养作用。在颅脑损伤、脑梗塞等急慢性颅脑损伤状况下,星形胶质细胞加倍释放S100B蛋白,刺激自身和小胶质细胞产生大量致炎因子和NO,导致神经元功能障碍。在各种颅脑损伤早期其浓度即出现升高,且升高程度与病情的分级及预后成正相关。因此,S100B可作为颅脑损伤早期诊断、病情分级及判断预后的一项特异性指标。掌握其神经毒性机理并加以调控,是颅脑损伤临床治疗的研究方向之一。
S100B protein is mainly secreted by astrocytes, with neurotrophic effects at physiological concentrations. In the brain injury, cerebral infarction and other acute and chronic brain injury conditions, astrocytes double release of S100B protein, stimulate their own and microglial cells produce a large number of proinflammatory cytokines and NO, leading to neuronal dysfunction. In a variety of early craniocerebral injury that its concentration is increased, and the degree of increase and the grade of the disease is positively related to the prognosis. Therefore, S100B can be used as a specific indicator of early diagnosis of brain injury, grading and prognosis prognosis. To master the mechanism of neurotoxicity and to regulate it is one of the research directions in the clinical treatment of craniocerebral injury.