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目的观察外科手术后腹泻患儿经两种不同药物治疗的临床疗效、安全性。方法选择2012年10月—2013年11月在青岛市妇女儿童医院接受手术,并术后发生急性腹泻的113例患儿作为研究对象。患儿均为急性起病(48 h内),临床表现多为大便性状、次数的改变,或部分伴发热、呕吐、脱水等。均符合中国小儿腹泻病的诊断标准。将患儿按照入院顺序随机分组,治疗组56例采用鞣酸蛋白酵母散配合治疗,对照组57例采用蒙脱石散配合治疗。比较治疗后的临床症状改善情况(大便次数和性状积分)、总有效率、腹泻的复发率和不良反应。结果给药72 h后,治疗组总有效率为98.2%,而对照组为78.9%。2组总有效率比较差异有统计学意义(χ2=10.70,P<0.05)。2组患儿排便次数和大便性状总积分较其治疗前均显著降低(P<0.05),且治疗组大便情况积分明显低于对照组(χ2=6.3,P<0.05)。给药1周后,治疗组复发率10.7%,对照组复发率26.3%。治疗组患儿经鞣酸蛋白酵母散联合治疗腹泻的复发率更低(χ2=7.60,P<0.05)。2组均无严重不良事件发生,其中治疗组1例患儿服药后有面色发红,对照组有2例患儿出现恶心、1例患儿出现食欲不振,均经延缓给药后得以缓解,未经专门处理。结论外科手术后腹泻患儿经鞣酸蛋白酵母散联合治疗的临床效果显著,安全性好,而且患儿恢复好。
Objective To observe the clinical efficacy and safety of two different drugs in children with surgical diarrhea after surgery. Methods A total of 113 children with acute diarrhea undergoing surgery at Qingdao Women and Children’s Hospital from October 2012 to November 2013 were selected as the study subjects. Children were acute onset (within 48h), clinical manifestations and more stool traits, the number of changes, or in part with fever, vomiting, dehydration and so on. Are in line with China’s diagnostic criteria for pediatric diarrhea. The children were randomized according to the order of admission, the treatment group of 56 patients treated with tannic acid yeast loose powder combined treatment, 57 patients in the control group treated with montmorillonite powder. Comparison of clinical symptoms after treatment to improve the situation (stool frequency and trait points), the total effective rate, the recurrence rate of diarrhea and adverse reactions. Results After 72 h, the total effective rate was 98.2% in the treatment group and 78.9% in the control group. The total effective rate in the two groups was significantly different (χ2 = 10.70, P <0.05). The total scores of defecation and stool in both groups were significantly lower than those before treatment (P <0.05), and the stool scores in the treatment group were significantly lower than those in the control group (χ2 = 6.3, P <0.05). One week after the administration, the recurrence rate was 10.7% in the treatment group and 26.3% in the control group. The treatment group had a lower relapse rate of diarrhea (χ2 = 7.60, P <0.05). There were no serious adverse events in the two groups. One patient in the treatment group had redness after taking the medication, two patients in the control group had nausea, one patient had anorexia and were relieved after the delayed administration, Without special treatment. Conclusions The clinical effect of tannic acid yeast powder combination therapy in children with postoperative surgical diarrhea is significant, safe and good in children.