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目的:研究细胞外基质蛋白酶诱导因子(EMMPRIN)和肝细胞生长因子(HGF)在非小细胞肺癌(NSCLC)组织中的表达及其临床意义。方法:免疫组织化学方法检测77例NSCLC组织中EMMPRIN与HGF的表达,分析其与患者吸烟情况、肿瘤大小、组织学类型、组织分化程度、淋巴结转移和预后的关系。结果:77例NSCLC组织中EMMPRIN与HGF的阳性表达率分别为68%和44%。EMMPRIN与HGF的表达均与淋巴结转移呈正相关(r=0.371和0.339,P<0.01),与患者术后生存时间呈负相关(P<0.01)。EMMPRIN与HGF的表达均与患者吸烟、肿瘤大小、组织学类型和组织分化程度无关(P>0.05)。EMMPRIN与HGF的表达之间呈正相关(r=0.281,P<0.01)。结论:EMMPRIN和HGF的表达与NSCLC的淋巴结转移和预后密切相关,它们的高表达提示NSCLC患者预后不良。
Objective: To investigate the expression and clinical significance of extracellular matrix protease inducer (EMMPRIN) and hepatocyte growth factor (HGF) in non-small cell lung cancer (NSCLC). Methods: Immunohistochemistry was used to detect the expression of EMMPRIN and HGF in 77 NSCLC tissues. The relationship between EMMPRIN and HGF expression was analyzed with smoking status, tumor size, histological type, histological grade, lymph node metastasis and prognosis. Results: The positive rates of EMMPRIN and HGF in 77 NSCLC tissues were 68% and 44%, respectively. The expressions of EMMPRIN and HGF were positively correlated with lymph node metastasis (r = 0.371 and 0.339, P <0.01), and negatively correlated with the postoperative survival time (P <0.01). The expressions of EMMPRIN and HGF were not associated with smoking, tumor size, histological type and histological grade (P> 0.05). There was a positive correlation between the expression of EMMPRIN and HGF (r = 0.281, P <0.01). Conclusion: The expressions of EMMPRIN and HGF are closely related to the lymph node metastasis and prognosis of NSCLC. The high expression of EMMPRIN and HGF suggests that the prognosis of patients with NSCLC is poor.