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本文从肿瘤免疫、自身免疫、感染免疫、移植免疫、免疫缺陷多方面综述了细胞因子和细胞因子网络的临床研究进展。目前用IFN-α、IL-2、TNF、特别是IL-2/LAK、IL-2/TIL 治疗肿瘤取得了良好的故果。但某些细胞因子在一定条件可促进肿瘤细胞的生长。IFN-γ、TNF、IL-1、IL-2、IL-6等可参与移植排斥反应和多种自身免疫性疾病的发生,用这些细胞因子(或其受体)的单抗或细胞因子与毒素的联结物可延缓移植物排斥反应并能治疗某些自身免疫病。感染所诱生的细胞因子如IFN、IL-1、IL-2、IL-6、TNF、CSF 等反过来可以抗御细菌、病毒和寄生虫的感染。有人用外源性细胞因子治疗免疫缺陷性疾病已取得了初步的效果。文中还讨论了有关该领域研究的现存问题并展望了细胞因子疗法的发展方向。
This review summarizes the progress of clinical research on cytokines and cytokines networks from aspects of tumor immunity, autoimmunity, infection immunity, transplantation immunity and immune deficiency. Currently, the treatment of tumors with IFN-α, IL-2, TNF, especially IL-2 / LAK, IL-2 / TIL has achieved good results. However, certain cytokines can promote the growth of tumor cells under certain conditions. IFN-γ, TNF, IL-1, IL-2, IL-6 and so on may participate in the transplant rejection and the occurrence of various autoimmune diseases. Using the monoclonal antibodies or cytokines of these cytokines (or their receptors) Toxin conjugates delay graft rejection and can treat certain autoimmune diseases. Infections of cytokines such as IFN, IL-1, IL-2, IL-6, TNF, CSF and the like can in turn be resistant to infections by bacteria, viruses and parasites. Some people have used the exogenous cytokine treatment of immunodeficiency disease has achieved initial results. The paper also discusses the existing problems in this field and looks forward to the development of cytokine therapy.