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目的观察血清中超敏C-反应蛋白(hs-CRP)在慢性阻塞性肺疾病急性加重期(AECOPD)患者治疗前后的变化。方法应用免疫透射比浊法对78例AECOPD患者治疗前和治疗后病情缓解时血清hs-CRP浓度进行检测,并与35例正常对照组进行比较。结果 AECOPD患者血清中hs-CRP水平[(51.25±6.5)μg/ml]明显高于正常对照组[(0.89±0.05)μg/ml],差异有统计学意义(P<0.01)。结论 hs-CRP是反映AECOPD患者肺部感染的敏感指标,是用来观察治疗效果良好的指标之一,对于评价AECOPD患者病情严重程度及预后有较好的评估价值。
Objective To observe the changes of serum hs-CRP levels in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) before and after treatment. Methods Serum hs-CRP concentrations were measured in 78 patients with AECOPD before and after treatment by immunoturbidimetry and compared with 35 normal controls. Results The serum levels of hs-CRP in AECOPD patients [(51.25 ± 6.5) μg / ml] were significantly higher than those in normal controls [(0.89 ± 0.05) μg / ml] (P <0.01). Conclusion hs-CRP is a sensitive indicator of pulmonary infection in patients with AECOPD. It is one of the indicators used to observe the effect of treatment and has a good evaluation value for evaluating the severity and prognosis of patients with AECOPD.