食道曲张静脉出血是肝硬化和门静脉高压患者最严重而又难以避免的并发症之一。食道静脉曲张确诊后1年内出血率可达55％,其中首次出血占1/3,1年内再度出血占70％,尤其是首次出血后3个月可再度出血。因此,对所有在内窥镜下诊断为食道静脉Ⅱ度曲张及发生首次出血的患者进行出血的预防十分重要。 本文研究用5-单硝酸异山梨醇酯对肝硬化食道曲张静脉出血的预防作用。5-单硝酸异山梨醇酯有直接扩张血管的作用,能有 Esophageal variceal bleeding is one of the most serious and unavoidable complications of cirrhosis and portal hypertension. Esophageal varices within 1 year after diagnosis of bleeding rate of up to 55%, of which 1/3 for the first time hemorrhage, re-bleeding within 1 year accounted for 70%, especially 3 months after the first hemorrhage bleeding again. Therefore, it is important to prevent bleeding in all patients diagnosed with grade II varices of the esophageal varices undergoing endoscopy and first-time bleeding. This article studies the use of isosorbide 5-mononitrate on the prevention of hepatic cirrhosis from esophageal variceal bleeding. Isosorbide mononitrate 5 has a direct dilation of blood vessels, can have