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研究甘草 ,升麻 ,枸杞 ,茴香 4种中药对去卵巢大鼠肝脏脂代谢的作用及机理。用上述 4种中药及雌激素灌胃 5周后观察药物对大鼠肝脏总胆固醇 (Tc) ,甘油三酯 (TG) ,雌二醇 (E2 ) ,孕酮(P) ,睾酮 (T) ,泌乳素 (PRL)的影响。结果 :模型大鼠去卵巢 6周后 ,肝内甘油三酯及胆固醇水平增加。子宫萎缩 ,服以上 4种中药后 ,TG、TC水平降低 ,子宫重量大于模型组 ,枸杞 ,甘草作用较为明显。服用雌激素与甘草提取液的去卵巢大鼠雌二醇的浓度 ,明显高于模型组 (P <0 0 5 )。说明 4种中药具有抗肝脂肪作用 ,机理不同 ,仅甘草具有植物雌激素作用
To study the effects and mechanism of four kinds of Chinese herbs on hepatic lipid metabolism in ovariectomized rats. After 5 weeks of gavage with the above 4 herbs and estrogens, the rats were observed for hepatic total cholesterol (Tc), triglyceride (TG), estradiol (E2), progesterone (P), and testosterone (T). Prolactin (PRL) effects. RESULTS: After 6 weeks of ovariectomy in model rats, intrahepatic triglyceride and cholesterol levels increased. Uterine atrophy, after taking more than four kinds of traditional Chinese medicine, TG, TC levels decreased, uterine weight greater than the model group, wolfberry, licorice effect is more obvious. The concentration of estradiol in ovariectomized rats taking estrogen and licorice extract was significantly higher than that in the model group (P < 0.05). Explain that the four kinds of Chinese herbs have anti-hepatic fat effects and the mechanism is different. Only licorice has phytoestrogenic effects.