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目的:通过分析中原地区冠心病患者血脂谱特征,探讨载脂蛋白B/载脂蛋白AI(ApoB/ApoAI)比值作为冠心病危险因素评估指标的必要性和优势。方法:冠状动脉造影确诊的正常对照组和冠心病患者,进行血脂及载脂蛋白生化分析,统计各血脂谱的相关性,比较各相关系数的差异。结果:①TC、LDL-C、non-HDL-C、ApoB、TC/HDL-C和ApoB/ApoAI各指标在冠心病组显著高于对照组(P<0.05)。②冠心病组HDL-C浓度在各水平分层的比例均明显低于对照组(P=0.002),而TC和LDL-C差异无统计学意义(P>0.05)。③LDL-C与non-HDL-C有最密切的相关性(r=0.959),两者与ApoB/ApoAI的相关性差异无统计学意义(P>0.05),而两者分别与ApoB/ApoAI的相关性与ApoB/ApoAI和ApoB、TC/HDL-C的相关性有显著差异(P<0.05)。结论:中原地区冠心病患者具有低HDL-C的特征,由于各血脂谱统计学相关性的显著差异,ApoB/ApoAI比值可能是反映此类患者心血管病风险的理想标志物和治疗靶点。
OBJECTIVE: To explore the necessity and advantages of serum lipids profile in patients with coronary heart disease in the Central Plains to explore the value of ApoB / ApoAI ratio as a risk factor for coronary heart disease. Methods: The normal control group and coronary heart disease patients diagnosed by coronary angiography were used to carry out biochemical analysis of blood lipids and apolipoproteins. The correlations among various lipid profiles were statistically analyzed and the differences of the correlation coefficients were compared. Results: ① The indexes of TC, LDL-C, non-HDL-C, ApoB, TC / HDL-C and ApoB / ApoAI in CHD group were significantly higher than those in control group (P <0.05). ② The ratio of HDL-C in coronary heart disease group was significantly lower than that in control group (P = 0.002), while there was no significant difference between TC and LDL-C (P> 0.05). The correlation between LDL-C and non-HDL-C was the most significant (r = 0.959), but there was no significant difference between them (P> 0.05), but both of them were correlated with ApoB / ApoAI Correlation with ApoB / ApoAI and ApoB, TC / HDL-C was significantly different (P <0.05). CONCLUSIONS: Patients with coronary heart disease in the Central Plains have characteristics of low HDL-C. The ApoB / ApoAI ratio may be an ideal marker and therapeutic target for reflecting the risk of cardiovascular disease in these patients due to the statistically significant differences in the lipid profiles.