H_2受体拮抗剂甲硫咪胺、甲氰咪胺、甲氰咪胍、甲硝呋胍等,是近年来应用于临床的一类新型抗溃疡药。它们不但能显著地抑制基础和夜间胃酸的分泌,并对组织胺、五肽胃泌素、咖啡因、胰岛素、氨乙吡唑、食物、刺激迷走神经等引起的胃酸分泌也有较强的抑制作用。临床主要用于胃、十二指肠溃疡及胃酸过多症等,疗效较好。随着此类药物临床疗效的肯定,目前应用也日益广泛,但其滥用现象及不合理的配伍时有所见,本文仅对其配伍及相互作用加以概述。 1.与促进溃疡愈合的药物伍用生胃酮能促进粘液分泌并增加其粘稠度,减少上皮细胞脱落,并延长其寿命;也能与胃蛋白酶结合,使胃蛋白酶及细胞 H_2 receptor antagonists methimamide, cimetidine, cimetidine, tolongidine, etc., is a new type of antiulcer drug used clinically in recent years. They not only significantly inhibit basal and nocturnal gastric acid secretion, but also have strong inhibitory effects on gastric acid secretion caused by histamine, pentagastrin, caffeine, insulin, amiloride, food, and vagus nerve stimulation. Clinical mainly for the stomach, duodenal ulcer and hyperacidity, etc., good effect. With the clinical efficacy of these drugs affirmed, the current application is also increasingly widespread, but the phenomenon of abuse and unreasonable compatibility have seen, this article only to its compatibility and interaction outlined. 1. With the promotion of ulcer healing drugs Wu Huoneperoxide can promote mucus secretion and increase its viscosity, reduce epithelial cell shedding, and extend its life; but also with pepsin, so pepsin and cells