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基质细胞衍生因子 (SDF 1)属CXC类趋化因子 ,其唯一受体为CXCR4。近年研究表明 ,SDF 1/CXCR4与多种恶性血液病的发生、发展有关。SDF 1/CXCR4可维持恶性血细胞的存活并促其增殖 ,还可通过调节黏附分子的功能参与恶性血液细胞在骨髓、淋巴结等器官的浸润。以SDF 1/CXCR4为靶分子的治疗有潜在的临床应用前景。
Stromal cell-derived factor (SDF 1) is a CXC chemokine whose sole receptor is CXCR4. Recent studies have shown that, SDF 1 / CXCR4 with a variety of malignant hematological diseases, the development. SDF 1 / CXCR4 can maintain the survival of malignant blood cells and promote its proliferation. It can also participate in the infiltration of malignant blood cells in the bone marrow, lymph nodes and other organs by regulating the function of adhesion molecules. Treatment with SDF 1 / CXCR4 as a target has potential clinical applications.