小鼠一次或多次腹腔注射醋酸铅后,分别投给DMSA、Na_2CaEDTA、DPA、Na_3CaDTPA 和DMPS 测定这几种络合剂降低肝、肾、脾、骨和脑组织铅含量的效应。结果发现,在一些实验条件下,用络合剂处理后小鼠肝、肾、骨和脑铅含量明显低于对照组。检测的几种络合剂中,不论腹腔注射还是胃管注入DMSA,其从组织中驱铅的能力均比其它种络合剂更有效。结果提示这种络合剂是有发展前途的,值得临床上深入研究。 After one or more intraperitoneal injections of lead acetate, mice were dosed with DMSA, Na_2CaEDTA, DPA, Na_3CaDTPA and DMPS respectively to determine the effect of these complexing agents on reducing lead in liver, kidney, spleen, bone and brain. The results showed that in some experimental conditions, the liver, kidney, bone and brain lead content of mice treated with complexing agent was significantly lower than that of the control group. Of the several complexing agents tested, whether injected intraperitoneally or with gastric tube, DMSA was more effective at removing lead from the tissues than other complexing agents. The results suggest that this complexing agent is promising, it is worth further study in the clinic.