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第二血脑屏障被发现 血脑屏障的结构程度可能要比我们原来想象的要复杂得多。美国俄勒冈州卫生学大学Muldoon博士及同事发现显然可以阻止药物从血液进入大脑的第二屏障。在《美国神经放射杂志》(American Journal of Neuroradiology)二月刊上报告了他们的发现。该研究小组具有20年的经验,采用一种打开第一血脑屏障(一种由内皮细胞紧密连接组成的解剖结构)传送抗癌药物的技术。但某些通过第一血脑屏障的药物显然在第二屏障(称为基底膜)受阻,绝不能到达大脑。最近,研究小组对啮齿动物中传送基因通过血脑屏障的途径进行了试验。将基因载在经改造的病毒载体如疱疹病毒载体或腺病毒
The second BBB was found to be more complex in structure than the one we originally imagined. Dr. Muldoon and colleagues at the Oregon State School of Hygiene discovered a second barrier that obviously blocked the blood from entering the brain. Their findings were reported in the February issue of the American Journal of Neuroradiology. The team has 20 years of experience using a technique that opens up the first blood-brain barrier, an anatomical structure composed of tight junctions of endothelial cells, to deliver anti-cancer drugs. But some drugs that cross the first blood-brain barrier are clearly blocked at the second barrier, called the basement membrane, and never reach the brain. Recently, the team has tested the way rodents transmit genes across the blood-brain barrier. The gene is carried in a modified viral vector such as a herpesvirus vector or adenovirus