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本文综述关于牙菌斑的药物控制(引用文献94篇—译注)。各类药物对牙菌斑的预防或消除,不论是在试管中或在活体上都表现出不同的效能。目前,尚无一种化疗药物能安全地授给而长期控制牙菌斑。抗菌素由于其全身性副作用和有限的抑菌谱,而只能作为短期牙菌斑控制剂。所有其他药物在使用上均受限制,是由于(1)具有不良或有毒的局部或全身性副作用,(2)缺乏有临床意义的效能,(3)实验证据不足。在下述领域内应作进一步探讨: 1.明确直接与牙病有关的牙菌斑组成。2.明确全部或部分地消灭口腔细菌对口腔组织和生态学系统的影响。3.发展无有害副作用的牙菌斑控制药物。
This article reviews the drug control of plaque (Reference 94). Various types of drugs on the plaque prevention or elimination, whether in vitro or in vivo have shown different efficacy. Currently, there is no one chemotherapy drug can be safely granted and long-term control of dental plaque. Antibiotics are only available as short-term dental plaque control agents due to their systemic side effects and limited antibacterial spectrum. All other drugs are limited in their use due to (1) adverse or noxious local or systemic side effects, (2) lack of clinically significant efficacy, and (3) inadequate experimental evidence. In the following areas should be further explored: 1. Determine the dental plaque directly related to the composition. 2. Clear all or part of the elimination of oral bacteria on oral tissue and ecological system. 3. Development of plaque-control drugs without harmful side effects.