论文部分内容阅读
目的：经肝动脉化疗栓塞已成为肝癌综合治疗的主要手段之一，为了最大限度地降低微球对癌外肝组织的损害，本研究采用磁性顺铂微球经肝癌大鼠肝动脉注入，观察其导向治疗作用。方法：首先将Ｗａｌｋｅｒ－２５６癌条接种于大鼠肝左叶被膜下，接种后７天肝癌大鼠随机分为４组，治疗组肝动脉注入磁性顺铂微球，肝癌部位的相应体表放置５２００Ｇ强磁场，并与肝动脉注入生理盐水、注入普通水剂顺铂、磁性顺铂微球体外不加磁场３个组进行比较。结果：治疗组的肝癌体积变化（Ｐ＜０．０１），肿瘤生长率（Ｐ＜０．０１），术后不同时期肝癌结节及正常肝组织中的铂的含量（Ｐ＜０．００１），ＳＧＰＴ含量（Ｐ＜０．０５）等观察指标缩小均显著优于其他各组。结论：磁性化疗栓塞微球在局部体外强磁场的导向作用下，经肝动脉注入后有着独特的导向治疗肝癌作用，且副作用小，值得临床应用。
OBJECTIVE: Transcatheter arterial chemoembolization has become one of the main methods for comprehensive treatment of liver cancer. In order to minimize the damage of microspheres to extrahepatic liver tissue, this study used magnetic cisplatin microspheres to infuse the hepatic artery of hepatocellular carcinoma rats. Its therapeutic effect. Methods: Walker-256 cancer strips were inoculated into the left hepatic membrane of rat liver. Seven days after inoculation, liver cancer rats were randomly divided into four groups. The treated group was injected with magnetic cisplatin microspheres into the hepatic artery. 5200G strong magnetic field, and with the injection of saline into the hepatic artery, injection of ordinary aqueous cisplatin, magnetic cisplatin microspheres without magnetic field in vitro 3 groups for comparison. Results: The volume of liver cancer in the treatment group changed (P<0.01), the tumor growth rate (P<0.01), and the content of platinum in liver cancer nodules and normal liver tissues at different stages after operation (P<0.001). The reduction of SGPT content (P<0.05) and other observational indexes were significantly better than those of other groups. Conclusion: The magnetic chemotherapy embolism microspheres have unique guidance effect for the treatment of liver cancer after hepatic arterial injection under the guidance of local strong external magnetic field, and the side effect is small, which is worthy of clinical application.