论文部分内容阅读
目的观察臭氧水毒性,以评价其使用安全性。方法采用动物试验方法对电解臭氧水进行了亚急性毒性试验。结果含臭氧量10 mg/L的臭氧水急性经口毒性试验期间未见试验动物出现中毒现象,对大、小鼠急性经口LD50均大于5000 mg/kg体重,属于实际无毒级。亚急性毒性试验各剂量组大鼠红细胞计数、血红蛋白含量、白细胞计数以及白细胞分类计数与对照组比较差异均无显著性(P>0.05)。各剂量组大鼠血清总蛋白、白蛋白、球蛋白、白/球比、谷丙转氨酶、谷草转氨酶、血糖、尿素氮、甘油三脂、肌酐、胆固醇与对照组比较差异均无显著性(P>0.05)。对处死动物的脏器大体解剖检查和病理学检验均未发现有意义的改变。结论含臭氧量为10 mg/L臭氧水大鼠急性经口毒性属实际无毒类,大鼠亚急性毒性试验未见异常,其最大未观察到有害作用剂量为1000 mg/kg体重。
Objective To observe the ozone water toxicity to evaluate the safety of its use. Methods Acute toxicity test of electrolyzed ozone water was carried out by animal experiment. Results Oral water containing 10 mg / L ozone had no poisoning in experimental animals during the acute oral toxicity test. The acute oral LD50 in both large and mice was more than 5000 mg / kg body weight, which belonged to the actual non-toxic grade. Subacute toxicity test in each dose group rats erythrocyte count, hemoglobin, white blood cell count and white blood cell count was no significant difference compared with the control group (P> 0.05). Serum total protein, albumin, globulin, white / globule ratio, alanine aminotransferase, aspartate aminotransferase, blood glucose, urea nitrogen, triglyceride, creatinine and cholesterol in each dose group had no significant difference > 0.05). No significant changes were found in the gross anatomy and pathological examination of organs of sacrificed animals. Conclusion The acute oral toxicity of ozone water containing 10 mg / L O3 water is an actual non-toxic group. No subacute toxicity test was found in rats. The maximum toxic dose of 1000 mg / kg body weight was not observed.