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目的 观察乐福至长期用药后对大鼠血象及重要器官组织形态学的影响。方法 选用wistar大鼠 ,口服给药剂量为 2 0g/kg、10 g/kg、1g/kg .d ,连续给药 6 0d ,分别在给药结束和停药 7d后进行血象及心、脑、肾等脏器的组织病理学检测。结果 三剂量组长期用药对大鼠血象无毒性影响 ,且显示有兴奋造血功能的作用。病理学研究未发现异常的毒性损伤性改变。结论 乐福至在相当于人用量 10 0倍时 ,对大鼠血象及器官组织形态学无任何影响。
Objective To observe the effects of Carrefour on long-term administration of blood and histomorphology of blood vessels in rats. Methods Wistar rats were selected and doses of 20 g/kg, 10 g/kg, and 1 g/kg.d were orally administered for 60 days. Blood and brain, brain, and brain were administered at the end of drug administration and 7 days after discontinuation, respectively. Histopathological examination of kidney and other organs. Results The long-term administration in the three-dose group had no toxic effects on the blood of the rats and showed the effect of excitatory hematopoietic function. Pathological studies have found no abnormal changes in toxic damage. Conclusion Carrefour did not affect the blood and organ morphology of rats at a time equivalent to 100 times the human dose.