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盐酸地卡因注射液为常用医院制剂。盐酸地卡因在碱性或中性溶液中,受热后酯链结构被水解,使含量下降。为增加制剂的稳定性,常用0.1N 盐酸调节pH 至4.0～4.5。北京市卫生局编《制剂手册》(1980,P383)采用银量法快速测定盐酸地卡因含量。该法未考虑制剂配制过程中调节pH 所用盐酸增加了溶液中Cl~-浓度,导致测定结果偏
Cocaine hydrochloride injection for the commonly used hospital preparations. Cocaine hydrochloride in alkaline or neutral solution, heated ester chain structure is hydrolyzed, the content decreased. To increase the stability of the preparation, 0.1N hydrochloric acid is often used to adjust the pH to 4.0-4.5. Beijing Municipal Health Bureau, “Preparation Manual” (1980, P383) silver content method for rapid determination of cocaine hydrochloride content. The method does not consider the preparation of the preparation of hydrochloric acid used to adjust the pH increased the concentration of Cl ~ - in the solution, resulting in the determination of partial results