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目的探讨洛汀新联合螺内酯治疗对重度心力衰竭患者心室重塑及心功能的影响。方法选择重度心力衰竭患者140例,随机分为治疗组和对照组,对照组给予常规治疗,治疗组在常规治疗的基础上,加用洛汀新联合螺内酯治疗。两组均连续用药治疗12周。评估两组患者治疗前后的心力衰竭症状评分和心功能NYHA分级,并进行超声心动图检查。结果经过12周的治疗,对照组临床症状、NYHA分级、心功能及心室重塑指标略有改善,而治疗组均明显改善(P<0.05)。结论重度心力衰竭患者在常规应用洛汀新联合螺内酯可明显改善患者的心功能和逆转心室重塑。
Objective To investigate the effects of Lotensin combined with spironolactone on ventricular remodeling and cardiac function in patients with severe heart failure. Methods 140 patients with severe heart failure were randomly divided into treatment group and control group. The control group was given routine treatment. The treatment group was treated with Lotensin plus spironolactone on the basis of routine treatment. Both groups were treated for 12 weeks. Heart failure symptom scores and NYHA classification were assessed before and after treatment in both groups, and echocardiography was performed. Results After 12 weeks of treatment, the clinical symptoms, NYHA classification, cardiac function and ventricular remodeling index improved slightly in the control group, and the treatment group were significantly improved (P <0.05). Conclusion The combination of Lotensin and spironolactone in patients with severe heart failure can significantly improve cardiac function and reverse ventricular remodeling.