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观察膀胱输尿管返流（ＶＵＲ）患儿Ｔａｍｍ－Ｈｏｒｓｆａｌ蛋白（ＴＨＰ）、血抗ＴＨＰ抗体变化及致肾损害关系。方法对２０例确诊ＶＵＲ患儿检测２４小时尿ＴＨＰ排量及血ＴＨＰ含量。结果重度返流１３例均明显降低，轻度返流７例与正常组比较无显著性差异。尿ＴＨＰ排量与尿β２－ｍ排量呈负相关。结论重度返流存在返流性肾损害，致肾小管ＴＨＰ分泌与合成功能障碍。血抗ＴＨＰ抗体未见升高，ＶＵＲ免疫性肾损害机制有待进一步证明。
To observe the relationship between Tamm-Horsfal protein (THP), blood anti-THP antibody and renal damage in children with vesicoureteral reflux (VUR). Methods Twenty patients with VUR diagnosed at 24 hours were tested for THP and THP contents. Results severe regurgitation in 13 cases were significantly lower, mild reflux in 7 cases compared with the normal group no significant difference. Urinary THP displacement and urinary β2-m displacement was negatively correlated. Conclusions Severe regurgitation has reflux renal damage, causing tubular THP secretion and synthesis dysfunction. Blood anti-THP antibody did not increase, VUR immune renal damage mechanism needs further evidence.