醛糖还原酶是糖代谢多元醇通路的限速酶。最新研究表明:心肌缺血时醛糖还原酶活性增强,抑制醛糖还原酶可以通过保护糖酵解途径和抑制氧化应激,减轻心肌缺血损伤,改善缺血再灌注后心肌功能。醛糖还原酶抑制剂作为潜在的治疗心肌梗死的有效措施引起了研究者的关注。 Aldose reductase is the rate-limiting enzyme in the glucose metabolism polyol pathway. Recent studies have shown that: aldose reductase activity increased myocardial ischemia, inhibition of aldose reductase by protecting the glycolytic pathway and inhibition of oxidative stress, reduce myocardial ischemic injury and improve myocardial function after ischemia-reperfusion. Aldose reductase inhibitors have attracted researchers’ attention as an effective measure to treat myocardial infarction.