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为了阐明心钠素（ANP）和抗利尿激素（ADH）在正常和缺氧新生儿生后早期体液平衡中的作用，测定了44例正常新生儿和36例缺氧新生儿生后第1、3、7天血浆心钠素（PANP）、抗利尿激素（PADH）以及血、尿各项指标。结果表明：正常新生儿生后第1天PANP和PADH都升高，两者之间存在着负相关关系；尿量、尿钠、尿渗透压和ANP呈正相关；缺氧新生儿的PANP和PADH均较正常儿升高，其第3天的尿量、尿钠和尿渗透压均显著高于正常新生儿同期水平，提示ANP在新生儿早期水钠平衡中起主要作用，ANP通过明显的排钠利尿代偿了由ADH所致的水潴留，有助于缺氧新生儿肺功能的恢复和肺水肿的吸收。
In order to elucidate the role of ANP and ADH in the early postnatal fluid balance of normal and hypoxic neonates, 44 normal and 36 neonatal hypoxic neonates were tested for their first, 3, 7 days plasma atrial natriuretic peptide (PANP), anti-diuretic hormone (PADH), and blood, urine indicators. The results showed that PANP and PADH were elevated on the first day after birth in normal neonates, there was a negative correlation between them; urine output, urine sodium, urine osmotic pressure and ANP were positively correlated; PANP and PADH Were higher than the normal children, the third day of urine volume, urinary sodium and urine osmolality were significantly higher than the normal newborns over the same period, suggesting that ANP plays an important role in the early neonatal sodium and water balance, ANP through obvious rows Sodium diuresis compensates for water retention caused by ADH and contributes to recovery of lung function and absorption of pulmonary edema in hypoxic neonates.