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心肌重构(myocardial remodeling)是指心脏在长期负荷增加的情况下,心肌及心肌间质在细胞结构、功能、数量及遗传表型方面出现的增生性变化,表现为心肌细胞肥大,胚胎基因和蛋白再表达,心肌间质纤维化,并伴有心肌细胞坏死和凋亡,结果导致心脏肥厚和心室壁僵硬度增加,最终心功能
Myocardial remodeling (myocardial remodeling) refers to the heart under long-term load increases, myocardial and myocardial interstitial cell structure, function, quantity and genetic phenotype of proliferative changes, manifested as cardiomyocyte hypertrophy, embryonic genes and Protein re-expression, myocardial interstitial fibrosis, and myocardial necrosis and apoptosis, resulting in increased cardiac hypertrophy and ventricular wall stiffness, the ultimate heart function