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本文旨在评价超选择性脑血管内灌注三尖杉酯碱与氨甲喋呤化疗恶性脑瘤的疗效。按条件选择了恶性脑瘤１０例，采用Ｓｅｌｄｉｎｓｅｒ氏股动脉插管，超选择性的将Ｍａｇｉｃ导管置入病侧颈内动脉的眼动脉分支以上，经导管用２０％甘露醇开放血脑屏障后将三尖杉酯碱０．１～０．４５ｍｇ／ｋｇ及氨甲喋呤０．１～０．２ｉｎｇ／ｋｇ各溶于１００ｍｌ生理盐水中，在１２０分钟内恒速灌注，每例化疗１～５次，全组共进行３０次化疗。结果表明，化疗后肿瘤体积缩小率平均为４６．１８％，总有效率为７０％，疗效较好，毒副作用小。
This article aims to evaluate the efficacy of hyper-selective intracerebral perfusion of harringtonine and methotrexate in the treatment of malignant brain tumors. 10 cases of malignant brain tumor were selected according to the conditions. Seldinser’s femoral artery cannulation was used to place the Magic catheter above the branches of the ophthalmic artery on the side of the internal carotid artery. After transcatheter opening of the blood-brain barrier with 20% mannitol The harringtonine 0.1 ~ 0.45mg / kg and methotrexate 0.1 ~ 0.2ing / kg each dissolved in 100ml saline, constant infusion in 120 minutes, each chemotherapy 1 to 5 times, The whole group conducted a total of 30 chemotherapy. The results showed that the average tumor volume reduction after chemotherapy was 46.18%, the total effective rate was 70%, the curative effect is good, and the side effects are small.