目的总结一例重症三氯乙烯药疹样皮炎引起脓毒症致死亡病例的临床经验教训。方法对一例重症三氯乙烯药疹样皮炎死亡病例的临床资料进行回顾性分析。结果重症多形红斑可转为大疱表皮坏死松解症;表皮大面积脱落、创面渗出过多导致的血容量过低是诱发脓毒血症的主要原因,对不能解释的心率增快,血钠、血氯和血渗透压增高,再次发热、病情反复,血降钙原素、C反应蛋白和乳酸增高应进行补液试验和中心静脉压监测,早期液体复苏应充分达标。结论重症三氯乙烯药疹样皮炎可致脓毒症,是该病死亡的重要原因之一,应遵循早监测、早发现、早预防和早治疗的原则,及时有效纠正低血容量并进行强力抗感染治疗。 Objective To summarize the clinical experience of a case of severe trichlorethylene eruptive dermatitis caused by sepsis. Methods A case of severe trichlorethylene eruption-like dermatitis clinical data were retrospectively analyzed. Results Severe erythema multiforme can be converted to bullous epidermal necrolysis; epidermal shedding a large area, wound exudate caused by too much hypovolemia is the main reason for the induction of sepsis, heart rate can not be explained faster, Blood sodium, blood chlorine and blood increased osmolality, fever again, the disease repeated, blood calcitonin, C-reactive protein and lactic acid should be rehydration test and central venous pressure monitoring, early liquid resuscitation should be fully satisfactory. Conclusion Severe trichlorethylene edematous dermatitis can cause sepsis, which is one of the important causes of death. It should follow the principle of early monitoring, early detection, early prevention and early treatment, timely and effective correction of hypovolemia and strong resistance Infection treatment.