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目的观察氨酚羟考酮联合牛痘疫苗致炎兔皮提取物治疗带状疱疹后遗神经痛的临床疗效及安全性。方法将入选的79例带状疱疹后遗神经痛患者随机分为两组,治疗组39例,予氨酚羟考酮片0.33g口服(3次/d),同时予牛痘疫苗致炎兔皮提取物针剂3.6U肌注(1次/d);对照组40例,予布洛芬胶囊0.3g口服(2次/d),并每天肌肉注射Vit Bl200mg和腺苷钴胺1.5mg各1次。结果治疗14d后,治疗组有效率为84.62%,对照组为65.00%,且两组患者的VAS评分和威斯康星简要疼痛目录评分各项评价指标均较治疗前有明显下降,治疗组的VAS评分也优于对照组,以上差异均有统计学意义(P均<0.05)。两组患者不良反应发生率的差异无统计学意义(P>0.10)。结论氨酚羟考酮联合牛痘疫苗致炎兔皮提取物治疗带状疱疹后遗神经痛疗效好,安全性高。
Objective To observe the clinical efficacy and safety of oxycodone combined with vaccinia vaccine induced rabbit skin epidermal neuralgia in the treatment of postherpetic neuralgia. Methods A total of 79 patients with postherpetic neuralgia were randomly divided into two groups. The treatment group (n = 39) received oxycodone 0.33 g orally (3 times daily) Intramuscular injection of 3.6U intramuscular injection (1 / d); control group of 40 cases, 0.3g of ibuprofen capsules orally (2 times / d), and daily intramuscular injection of Vit Bl200mg and adenosylcobalamin 1.5mg 1 . Results After treatment for 14 days, the effective rate was 84.62% in the treatment group and 65.00% in the control group. VAS scores and scores of Wisconsin short-term pain score in both groups were significantly lower than those before treatment, and VAS scores in the treatment group Which is better than the control group, the above differences were statistically significant (all P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.10). Conclusion Paracetamol combined with vaccinia vaccine induced inflammation rabbit skin extract for the treatment of postherpetic neuralgia efficacy, high safety.