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目的:探讨乙型肝炎血清学标志物的不同模式与前S1抗原(Pre-S1Ag)的关系。方法:应用酶联免疫吸附法(ELISA)对12 972例患者和健康体检者的血清进行乙型肝炎病毒(HBV)血清学模式的检测,根据乙型肝炎表面抗原(HBsAg)的结果分为阴性组和阳性组。结果:HBsAg阳性组Pre-S1Ag阳性率为58.4%,HBsAg阴性组Pre-S1Ag阳性率为1.4%;HBsAg阳性组的血清学模式主要有6种,以HBsAg(+)、HBeAg(+)、HBcAb(+)、HBsAg(+)、HBeAg(+)模式Pre-S1Ag阳性率最高,占87.3%。HBsAg阴性组的血清学模式主要有7种,Pre-S1Ag阳性率0%~6.1%,不同的HBV血清学模式Pre-S1Ag阳性率也有很大差异。结论:乙型肝炎病毒Pre-S1Ag的测定在不同乙型肝炎血清学标志物模式中均有重要意义,能对HBV的感染、复制程度做出准确的判断,为临床治疗方案的选择和疗效的观察提供可靠的依据。
Objective: To investigate the relationship between different patterns of hepatitis B serological markers and pre-S1 antigen (Pre-S1Ag). Methods: Serum of 12 972 patients and healthy volunteers were tested for hepatitis B virus (HBV) serology by enzyme-linked immunosorbent assay (ELISA), and were classified as negative according to the results of hepatitis B surface antigen (HBsAg) Group and positive group. Results: The positive rate of Pre-S1Ag in HBsAg-positive group was 58.4%, while the positive rate of Pre-S1Ag in HBsAg-negative group was 1.4%. The serological patterns of HBsAg-positive group included 6 kinds of HBsAg, HBeAg (+), HBsAg (+), HBeAg (+) Pre-S1Ag positive rate of the highest, accounting for 87.3%. Serological patterns of HBsAg negative group mainly 7 kinds, Pre-S1Ag positive rate of 0% to 6.1%, different HBV serology Pre-S1Ag positive rate is also very different. Conclusion: The determination of Pre-S1Ag of hepatitis B virus is of great significance in different serological markers of hepatitis B. It can make an accurate judgment on the level of HBV infection and replication and provide a basis for the selection and curative effect of clinical treatment Observe to provide a reliable basis.