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目的 以糖尿病视网膜病变患者为研究对象，分析激光光凝联合抗血管内皮生长因子(VEGF)药物的不同使用时机对临床疗效的影响，为进一步提高糖尿病视网膜病变治疗效果寻找有效方法?方法 选择我院于2018年4月至2021年4月收治的62例糖尿病视网膜病变患者，平均分组?观察组患者的治疗方法为先采取抗VEGF 治疗，再进行激光光凝;对照组患者的治疗方法为先采取激光光凝，再实施抗VEGF 治疗，评估两组治疗效果差异?结果 治疗7d以及治疗14d后的视力校正结果分别为(0.49±0.16)分?(0.67±0.13)分，“,”Objective To analyze the effect of different time of laser photocoagulation combined with anti VEGF drugs on the clinical effcacy of patients with diabetic retinopathy，and to ?nd an effective way to further improve the therapeutic effect of diabetic retinopathy.Methods A total of 62 patients with diabetic retinopathy treated in our hospital from April 2018 to April 2021 were selected.After the average grouping，the treatment of the observation group was as follows: ?rst，the anti VEGF treatment was applied，followed by laser photocoagulation.The treatment method of the control group was: ?rst take laser photocoagulation，then implement anti VEGF treatment，and evaluate the difference of treatment effect.Results The visual acuity correction results showed that the visual acuity correction results after 7 days and 14 days of treatment were (0.49±0.16) and (0.67±0.13) respectively，the relevant data were signi?cantly improved in the control group (t=4.669?7.129，P=0.001?0.001).The thickness of macular fovea in the observation group was (301.44±18.22) ?m and (277.34±15.97) ?m after 7 days and 14 days of treatment，respectively，which was signi?cantly better than that in the control group (t=2.622，6.217;P=0.011，0.001).The incidence of complications after treatment of diabetic retinopathy in the observation group was only 9.68%，lower than that in the control group (35.48%)，with signi?cant difference (χ^2=4.521，P=0.033).Conclusion In the clinical treatment of diabetic retinopathy，the application of anti VEGF drugs before laser photocoagulation can achieve a more satisfactory therapeutic effect.This therapy can help reduce the incidence of complications and promote the recovery of visual acuity.