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动脉粥样硬化是引起冠状动脉粥样硬化性心脏病的主要因素之一。基质金属蛋白酶(MMPs)可影响动脉硬化斑块的去稳定化,MMP-2和MMP-9降解斑块部位的纤维帽,促进平滑肌细胞从中层迁移到内膜,加重了血管的结构改变,促进动脉粥样硬化斑块不稳定性的发生,使斑块易于破裂。本文对此进行简要阐述,并介绍了对MMP-2和MMP-9具有抑制作用的药物。
Atherosclerosis is one of the main factors that cause coronary atherosclerotic heart disease. Matrix metalloproteinases (MMPs) can affect the destabilization of atherosclerotic plaques. MMP-2 and MMP-9 can degrade the fibrous cap at the plaque and promote the migration of smooth muscle cells from the middle to the intima, which aggravate the structural changes of blood vessels and promote The occurrence of atherosclerotic plaque instability, plaque prone to rupture. This article briefly describes this and describes the drugs that have an inhibitory effect on MMP-2 and MMP-9.