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目的:观察赶黄草复方治疗酒精性脂肪肝(AFLD)的临床疗效,并探讨其作用机制。方法:将90例酒精性脂肪肝患者随机分为治疗组和对照组,各45例。对照组给予多烯磷脂酰胆碱静脉滴注治疗,治疗组除给予多烯磷脂酰胆碱滴注外,口服赶黄草复方。两组疗程均为4周,观察治疗前后两组临床疗效、肝功能、血脂、肝脏影像变化及药物不良反应。结果:治疗组总有效率为80%,对照组为60.22%,治疗组优于对照组(P<0.05)。治疗组在改善患者临床症状(乏力、黄疸、纳差、便溏),肝功能[丙氨酸氨基转移酶(ALT),谷酰转肽酶(GGT),γ-谷氨酰胺基转移酶(γ-GT)],血脂方面[甘油三酯(TG),低密度脂蛋白(LDL-C)]均优于对照组(P<0.05)。结论:赶黄草复方治疗酒精性脂肪肝疗效确切,值得深入研究促进临床应用。
Objective: To observe the clinical curative effect of Phellinus igniarius compound on alcoholic fatty liver (AFLD) and to explore its mechanism. Methods: 90 patients with alcoholic fatty liver were randomly divided into treatment group and control group, 45 cases each. The control group given polyene phosphatidylcholine intravenous infusion treatment, the treatment group given polyene phosphatidylcholine instillation, Oral catch Huangcao compound. The two courses of treatment were 4 weeks, before and after treatment to observe the clinical efficacy, liver function, blood lipids, liver changes and adverse drug reactions. Results: The total effective rate was 80% in the treatment group and 60.22% in the control group. The treatment group was better than the control group (P <0.05). The treatment group was significantly improved in improving clinical symptoms (fatigue, jaundice, anorexia, defecation), liver function [alanine aminotransferase (ALT), glutamyl transpeptidase (GGT), gamma glutamyltransferase γ-GT)], blood lipid [triglyceride (TG), low density lipoprotein (LDL-C)] were better than the control group (P <0.05). Conclusion: Phellinus comatus compound treatment of alcoholic fatty liver is effective, it is worth further study to promote clinical application.