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目的探讨人表皮生长因子受体2(HER-2/neu)和环氧合酶2(COX-2)在胃癌组织中的表达及临床意义。方法选取手术切除并经病理证实的胃癌存档腊块42例,采用免疫组化法检测胃癌及癌旁组织中HER-2/neu和COX-2的表达水平,分析其阳性表达与临床病理的关系。结果 42例中,胃癌组织HER-2/neu阳性表达率为23.8%,癌旁组织未见HER-2/neu表达;胃癌组织COX-2阳性表达率高于癌旁组织(59.5%vs.9.5%)(P<0.01)。胃癌组织中HER-2/neu和COX-2的表达呈正相关(r=0.33,P<0.05)。HER-2/neu和COX-2的阳性表达与胃癌浸润程度、淋巴结转移和TNM分期密切相关(P<0.05)。结论 HER-2/neu和COX-2在胃癌组织中的高表达与胃癌的发生、发展及转移密切相关。
Objective To investigate the expression and clinical significance of human epidermal growth factor receptor 2 (HER-2 / neu) and cyclooxygenase-2 (COX-2) in gastric cancer. METHODS: Forty-two cases of surgically resected and pathologically confirmed gastric cancellous wax pieces were collected. The expression of HER-2 / neu and COX-2 in gastric cancer tissues and adjacent normal tissues was detected by immunohistochemistry. The relationship between the expression of HER-2 / neu and COX- . Results The positive expression rate of HER-2 / neu in gastric cancer tissues was 23.8% and HER-2 / neu was not found in adjacent tissues. The positive rate of COX-2 expression in gastric cancer tissues was higher than that in paracancerous tissues (59.5% vs 9.5 %) (P <0.01). The expressions of HER-2 / neu and COX-2 in gastric cancer tissues were positively correlated (r = 0.33, P <0.05). The positive expression of HER-2 / neu and COX-2 was closely related to the degree of gastric cancer invasion, lymph node metastasis and TNM stage (P <0.05). Conclusion The high expression of HER-2 / neu and COX-2 in gastric cancer is closely related to the occurrence, development and metastasis of gastric cancer.