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目的 探讨甘泰康对大鼠免疫性肝纤维化的影响。方法 采用猪血清腹腔注射 ( 0 5ml/鼠 )建立大鼠免疫性肝纤维化模型 ,干预组造模同时给予甘泰康 ( 0 2 7g/kg·bw)灌胃 ,7周后采血 ,测定血清透明质酸 (HA)、层粘连蛋白 (LN)、III型前胶原 (PCIII)含量 ;取肝组织 ,常规切片 ,Masson、James染色后光镜下观察肝组织病理改变 ,病理图像系统半定量分析胶原纤维、网状纤维的增生情况。结果 甘泰康可有效对抗猪血清所致大鼠血清HA、LN、PCIII含量升高 ,有效对抗猪血清所致大鼠肝组织内胶原纤维、网状纤维增生。结论 甘泰康对猪血清诱导的大鼠免疫性肝纤维化有一定的防治作用。
Objective To investigate the effect of Gan Taikang on immune hepatic fibrosis in rats. Methods Rat model of autoimmune hepatic fibrosis was established by intraperitoneal injection of porcine serum (0 5ml / mouse). Ganshoukang (0 27g / kg · bw) was given to the intervention group at the same time and blood was taken 7 weeks later. Liver tissue, routine sections, Masson, James staining were observed under light microscope pathological changes of liver tissue, semi-quantitative analysis of pathological imaging system of collagen (collagen), laminin (LN), type III procollagen The proliferation of fiber, reticular fibers. Results Gan Taikang can effectively antagonize the serum of pig serum-induced HA, LN, PCIII levels increased effectively against pig serum-induced liver fibrosis in rats, reticular fibrosis. Conclusion Gan Taikang has some preventive and therapeutic effects on porcine serum-induced immune liver fibrosis.