糖尿病（ＤＭ）可通过多种机制促进血管性病变和（或）血栓性疾病的发生，血管内皮细胞损伤与血小板活化是其中两个最主要的因素。在这个过程中花生四烯酸代谢紊乱起着重要的作用。近年来人们发现了一些新的前列腺素物质并逐渐认识到它们的生理、病理与药理意义〔１〕。最近我 Diabetes mellitus (DM) can promote the development of vascular lesions and / or thrombotic diseases through a variety of mechanisms. Vascular endothelial cell damage and platelet activation are two of the most important factors. In this process, arachidonic acid metabolism plays an important role. In recent years, people have found some new prostaglandin substances and gradually realized their physiological, pathological and pharmacological significance [1]. Recently I