目的:观察龙胆泻肝汤联合水飞蓟宾胶囊治疗非酒精性脂肪肝的临床疗效。方法:将110例非酒精性脂肪肝肝胆实火上炎证患者随机分为对照组和治疗组各55例,在一系列改变不良生活方式的基础上,对照组给予水飞蓟宾胶囊治疗,治疗组给予龙胆泻肝汤联合水飞蓟宾胶囊治疗,观察2组的临床治疗效果,治疗前后测量患者的体质量指数、肝功能指标[谷丙转氨酶(ALT)、谷草转氨酶(AST)]和血脂指标[总胆固醇(TC)、甘油三酯(TG)],观察2组治疗后临床症状(乏力、纳差、腹胀、肝肿大)的改善情况。结果:对照组总有效率为78.18%,治疗组总有效率为92.73%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组ALT、AST和TC、TG均较治疗前下降(P<0.05),治疗组改善情况优于对照组(P<0.05);2组体质量指数均较治疗前下降(P<0.05),但组间对比,差异无统计学意义(P>0.05)。2组患者的乏力、纳差、腹胀、肝肿大均有所好转,治疗组各项症状的改善率均高于对照组,差异均有统计学意义(P<0.05)。结论:龙胆泻肝汤联合水飞蓟宾胶囊治疗非酒精性脂肪肝肝胆实火上炎证可改善患者的临床症状,恢复肝功能,调节血脂水平,是一种相对理想的治疗方法。 Objective: To observe the clinical efficacy of Longdan Xiegan Decoction combined with silybin in the treatment of non-alcoholic fatty liver disease. Methods: A total of 110 non-alcoholic fatty liver and gallbladder syndrome patients were randomly divided into control group and treatment group of 55 cases. On the basis of a series of changes of unhealthy life style, the control group was treated with silybin capsule, The treatment group was treated with Longdan Xiegan Decoction combined with silybin capsule. The clinical effect of the two groups was observed. The body mass index, liver function index (ALT, AST) of the patients were measured before and after treatment. And total cholesterol (TC) and triglyceride (TG)]. The clinical symptoms (fatigue, anorexia, abdominal distension and hepatomegaly) in two groups were observed. Results: The total effective rate of the control group was 78.18%, and the total effective rate of the treatment group was 92.73%. There was significant difference between the two groups (P <0.05). After treatment, the levels of ALT, AST, TC, TG in two groups were significantly lower than those before treatment (P <0.05), and the improvement in treatment group was better than that in control group (P <0.05) 0.05), but there was no significant difference between the two groups (P> 0.05). The fatigue, anorexia, abdominal distension and hepatomegaly were all improved in the two groups. The improvement rates of the symptoms in the treatment group were all higher than those in the control group, with significant differences (P <0.05). Conclusion: The combination of Longdan Xiegan Decoction and Silybin Capsule in the treatment of non-alcoholic fatty liver and gallbladder fire can improve clinical symptoms, restore liver function and regulate blood lipid level, which is a relatively ideal treatment.