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目的:观察大剂量胸腺肽对急性白血病化疗患者院内感染的干预作用及其作用机制。方法:42 例患者在化疗的同时使用大剂量的胸腺肽治疗(200 mg/d静脉滴注,连用14 d ~ 18 d),对照组单独使用化疗,方案与观察组相同。对两组患者的感染率、死亡率进行调查,对治疗前后的细胞免疫功能进行检测并进行相应的统计学处理。结果:观察组院内感染率及病死率明显低于对照组(P<0.05及P<0.01),治疗后观察组患者的细胞免疫功能(T4、T4/T8及NK细胞活性)明显高于对照组(P<0.05及P<0.01)。结论:大剂量胸腺肽在增加化疗效果的同时可显著增强机体的细胞免疫功能,增加机体的抗感染能力,降低院内感染的发生率及相关死亡率。
Objective: To observe the intervention effect of high-dose thymosin on nosocomial infection in patients with acute leukemia and its mechanism. Methods: Forty-two patients were treated with high-dose thymosin (200 mg / d for 14 days to 18 days). The control group was treated with chemotherapy alone. The protocol was the same as the observation group. Infection rate and mortality rate of two groups of patients were investigated, the cellular immune function before and after treatment was detected and the corresponding statistical analysis. Results: Infection rate and mortality in the observation group were significantly lower than those in the control group (P <0.05 and P <0.01). After treatment, the cellular immune function (T4, T4 / T8 and NK cell activity) in the observation group was significantly higher than that in the control group (P <0.05 and P <0.01). Conclusion: The high-dose thymosin can significantly enhance the cellular immune function, increase the anti-infective ability of the body, reduce the incidence of nosocomial infection and the related mortality while increasing the chemotherapy effect.