实体瘤生长具有血管生成依赖性。内皮细胞的增生、移动、管道形成是血管生成所必须的步骤，ＴＮＰ－４７０通过阻滞内皮细胞增生而抑制新血管形成，从而发挥抗癌作用。研究证实，ＴＮＰ－４７０可抑制肾癌生长、转移及新血管形成，在肿瘤早期应用其抗血管生成活性更为明显。并且，血管生成抑制剂和其他方案联合应用是一条新的思路 Solid tumor growth has angiogenic dependence. Endothelial proliferation, migration, and duct formation are necessary steps in angiogenesis. TNP-470 exerts anticancer effects by blocking endothelial cell proliferation and inhibiting new blood vessels. Studies have shown that TNP-470 can inhibit renal cell carcinoma growth, metastasis and neovascularization, its anti-angiogenic activity in the early stage of the tumor is more obvious. And angiogenesis inhibitors and other programs combined is a new idea