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目的 了解心肌特异性肌钙蛋白I(cTnI)对病毒性心肌炎的诊断价值。方法 用双抗ELISA法动态测定 46例病毒性心肌炎患者的血清cTnI,同时检测肌酸激酶同功酶 (CK MB)。结果 46例患者cTnI的阳性率为 80 4% ,CK MB的阳性率为 45 7% (P <0 0 5 )。病程 15天cTnI的检出率为 80 4% ,而CK MB的检出率为 2 1 3 % (P <0 0 1)。病程 6 0天cTnI的检出率为 2 4 4% ,而CK MB正常。结论 cTnI诊断病毒性心肌炎较CK MB具有更高的敏感性和持异性 ,诊断窗口时间较CK MB长。测定cTnI有助于病毒性心肌炎的早期诊断和了解疾病进展。
Objective To investigate the diagnostic value of cardiac troponin I (cTnI) in viral myocarditis. Methods Serum cTnI of 46 patients with viral myocarditis was measured by double-antibody ELISA. Creatine kinase isoenzyme (CK MB) was detected simultaneously. Results The positive rate of cTnI in 46 patients was 80 4% and the positive rate of CK MB was 45 7% (P0 05). The detection rate of cTnI in 15 days was 80 4%, while that of CK MB was 21 3% (P 0 01). Course 60 days cTnI detection rate was 24.4%, while the CK MB normal. Conclusions cTnI has higher sensitivity and specificity in diagnosing viral myocarditis than CK MB, and the diagnosis window time is longer than that of CK MB. Determination of cTnI contributes to the early diagnosis of viral myocarditis and to understand the progress of the disease.