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子宫内膜异位症是一种妇科常见的难治性疾病,药物治疗对于缓解症状、减少复发发挥重要的作用。既往作用于下丘脑-垂体-性腺轴的多种药物在临床应用中取得了肯定的疗效,近年提出以局部病灶为作用靶点进行治疗。现对孕激素拮抗剂、选择性孕激素受体调节剂、芳香化酶抑制剂、抗血管生成治疗及抗炎免疫调节治疗等在异位子宫内膜基础及临床研究中的进展予以综述。
Endometriosis is a common refractory disease in gynecology. Medication plays an important role in relieving symptoms and reducing recurrence. Previously applied to the hypothalamus - pituitary - gonadal axis of a variety of drugs in clinical application has made a positive effect, in recent years proposed to focus on the treatment of local lesions. The progress in the basic and clinical researches of ectopic endometrium is reviewed nowadays, including progestin antagonists, selective progestin receptor modulators, aromatase inhibitors, anti-angiogenic therapy and anti-inflammatory immunomodulatory therapy.