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目的探讨阿托伐他汀的药理作用以及临床效果。方法 80例患者均确诊为家族性高胆固醇血症,给予阿托伐他汀,1次/d,晚餐后以水送服,每次10mg。2个疗程后检测总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL-C)、低密密度脂蛋白(LDL-C)、C反应蛋白(CRP),并与治疗前比较。结果治疗后,患者平均HDL-C上升,平均TC、TG、LDL-C、CRP下降,数据经统计学比较具有显著差异(P<0.05)。治疗过程中,5例患者(6.25%)出现不同程度的食欲下降,但询诊均在患者可耐受范围内,未发生不可耐受不良反应。结论阿托伐他汀治疗家族性高胆固醇血症具有较好的临床疗效和安全性,其药理作用主要在于抑制羟甲基戊二酰辅酶、抑制极低密度脂蛋白胆固醇、促进低密度脂蛋白受体表达、促进高密度脂蛋白浓度增高、抑制TG生成、降低TC等。
Objective To investigate the pharmacological effects and clinical effects of atorvastatin. Methods 80 patients were diagnosed as familial hypercholesterolemia, given atorvastatin, 1 / d, after dinner with water delivery, each 10mg. After two courses of treatment, the levels of total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL-C), low density lipoprotein (LDL-C) and C-reactive protein (CRP) Compare Results After treatment, the average HDL-C increased, the average TC, TG, LDL-C, CRP decreased, the data were statistically significant differences (P <0.05). During the course of treatment, 5 patients (6.25%) experienced different degrees of appetite decline, but the inquiry was within the tolerable range of the patients without any intolerable adverse reactions. Conclusion Atorvastatin treatment of familial hypercholesterolemia with good clinical efficacy and safety of its pharmacological effects mainly inhibit hydroxymethyl glutaryl coenzyme, inhibit very low density lipoprotein cholesterol, promote low-density lipoprotein by Body expression, promote high-density lipoprotein concentration, inhibit TG formation, reduce TC and so on.