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目的探讨胸腺肽联合抗生素治疗老年慢性支气管炎急性发作期的临床疗效。方法选取2014年6月—2015年7月赣县人民医院收治的老年慢性支气管炎急性发作期患者90例,随机分为研究组与参照组,各45例。参照组给予常规抗生素治疗,研究组在参照组基础上加用胸腺肽治疗。治疗8d后,比较两组患者临床症状和体征消失时间(包括咳嗽、咳痰消失时间、呼吸困难消失时间、肺部啰音消失时间、退热时间及住院时间)、临床疗效及不良反应发生率。结果研究组患者咳嗽、咳痰消失时间、呼吸困难消失时间、肺部啰音消失时间、退热时间及住院时间短于参照组,总有效率高于参照组,差异有统计学意义(P<0.05)。治疗后,参照组患者未发生不良反应,研究组出现1例皮肤局部小丘疹,在停药以后自行消退。结论胸腺肽联合抗生素治疗老年慢性支气管炎急性发作期的临床疗效明显,可有效改善患者的临床症状,提高患者生活质量。
Objective To investigate the clinical efficacy of thymosin combined with antibiotics in the treatment of acute exacerbation of senile chronic bronchitis. Methods 90 patients with acute exacerbation of chronic bronchitis admitted to Ganxian People’s Hospital from June 2014 to July 2015 were randomly divided into study group and reference group, 45 cases in each group. The reference group was given conventional antibiotics, and the study group was treated with thymosin on the basis of the reference group. After 8 days of treatment, clinical symptoms and signs disappeared (including cough, sputum disappearance time, breathlessness disappearance time, pulmonary rales disappearance time, fever time and hospital stay), clinical efficacy and adverse reactions were compared between the two groups . Results The cough, the disappearance of sputum, the disappearance of dyspnea, the disappearance of pulmonary rales, the time of fever relief and hospital stay in the study group were shorter than those in the reference group, and the total effective rate was significantly higher than that in the reference group (P < 0.05). After treatment, no adverse reactions occurred in the reference group of patients. One case of skin papules in the study group developed spontaneous regression after withdrawal. Conclusion The clinical efficacy of thymosin combined with antibiotics in treating acute exacerbation of senile chronic bronchitis is obvious, which can effectively improve the clinical symptoms and improve the quality of life of patients.