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目的:探讨持续性变应性鼻炎患者鼻中隔软骨及骨性鼻中隔中的神经肽含量较正常个体有无变化,从而探讨鼻中隔矫正手术对于变应性鼻炎的治疗意义。方法:接受鼻中隔黏膜下切除术患者45例,其中持续性变应性鼻炎患者20例,单纯性鼻中隔偏曲患者25例。以放射免疫分析法测定手术切除的鼻中隔软骨及骨性鼻中隔中的神经肽SP、VIP及CGRP含量,并比较其差异。结果:正常组骨性鼻中隔中SP、VIP及CGRP含量较鼻中隔软骨高(P<0.05);鼻炎组鼻中隔软骨与骨性鼻中隔中SP、VIP含量无明显差异(P>0.05),鼻中隔软骨中CGRP含量较骨性鼻中隔高(P<0.05);鼻炎组鼻中隔软骨中SP、VIP含量较正常组高(P<0.05),CGRP含量无明显差异(P>0.05),骨性鼻中隔中SP、VIP及CGRP含量较正常组无明显差异(P>0.05)。结论:持续性变应性鼻炎患者鼻中隔中神经肽含量较正常个体增高,主要是鼻中隔软骨中的神经肽增高,因此鼻中隔黏骨膜下切除术后,变应性鼻炎能够得到缓解。
Objective: To investigate whether nasal septum cartilage and nasal septum in patients with persistent allergic rhinitis have more neuropeptides than those in normal individuals, so as to explore the therapeutic significance of nasal septum corrective surgery for allergic rhinitis. Methods: Forty-five patients undergoing nasal septum submucosal resection were selected, including 20 patients with persistent allergic rhinitis and 25 patients with simple deviation of nasal septum. Radioimmunoassay was used to determine the contents of SP, VIP and CGRP in nasal septal cartilage and nasal septum. The differences were compared. Results: The content of SP, VIP and CGRP in nasal septum of normal group were significantly higher than that of nasal septum cartilage (P <0.05). There was no significant difference in the content of SP and VIP between nasal septum cartilage and bony septum in rhinitis group (P> 0.05) The levels of SP and VIP in nasal septum cartilage of rhinitis group were significantly higher than those in normal group (P <0.05), but there was no significant difference in CGRP content (P> 0.05) CGRP content than the normal group no significant difference (P> 0.05). CONCLUSIONS: The content of neuropeptides in nasal septum of patients with persistent allergic rhinitis is higher than that of normal individuals. The neuropeptides in nasal septum cartilage are increased mainly. Therefore, allergic rhinitis can be relieved after submembranous resection of nasal septum.