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应用放射配体结合法测定了12例未用糖皮质激素的系统性红斑狼疮女性患者外周血糖皮质激素受体的变化,发现所有患者糖皮质激素受体少于正常人;同时应用放射免疫分析法测定了患者血浆皮质醇,结果与正常人无明显差异;提示系统性红斑狼疮时糖皮质激素—糖皮质激素受体系统异常,本文对这一异常的意义做了探讨。
Radioligand binding assay was used to determine the changes of glucocorticoid receptor in peripheral blood of 12 female patients with systemic lupus erythematosus without glucocorticoids and found that all patients had less glucocorticoid receptor than normal subjects. Meanwhile, radioimmunoassay The plasma cortisol was measured in patients with no significant difference with normal subjects. It suggested that the glucocorticoid-glucocorticoid receptor system was abnormal in patients with systemic lupus erythematosus. This article discusses the significance of this abnormality.