论文部分内容阅读
目的:探讨体外加腔内照射治疗中晚期宫颈癌的临床疗效和不良反应。方法:选择我院1994年12月～1998年12月收治的117例Ⅱb、Ⅲ期宫颈癌患者进行60Co体外放射加192Ir源高剂量率后装腔内治疗,全盆外照射46～50Gy,腔内放疗4～6Gy/次,1次/周,A点总量30～40Gy,疗程为6～7周。结果:全组117例患者总的5年生存率为62.4%,其中Ⅱb期67.9%,Ⅲ期57.8%。盆腔内复发率42.1%,远处转移率57.9%。远期合并症放射性直肠炎6.8%,放射性膀胱炎5.1%,子宫积液0.9%,阴道狭窄35.9%。结论:体外加腔内照射治疗中晚期宫颈癌疗效肯定,其预后与诸多因素有关,如何降低远期并发症有待临床进一步研究。
Objective: To investigate the clinical efficacy and side effects of in vitro and in-vivo irradiation on advanced cervical cancer. Methods: One hundred and seventy-one patients with stage IIb and III cervical cancer admitted to our hospital from December 1994 to December 1998 were treated with high-dose radiation of 60Co in vitro and 192Ir source. Radiotherapy 4 ~ 6Gy / time, 1 time / week, A total of 30 ~ 40Gy, treatment for 6 to 7 weeks. Results: The overall 5-year survival rate of 117 patients was 62.4%, of which 67.9% were in stage Ⅱb and 57.8% in stage Ⅲ. Pelvic recurrence rate was 42.1% and distant metastasis rate was 57.9%. Long-term complications of radiation proctitis 6.8%, radiation cystitis 5.1%, uterine effusion 0.9%, 35.9% of vaginal stenosis. Conclusion: In vitro and in vivo treatment of advanced cervical cancer with certain effect, its prognosis and many other factors, how to reduce the long-term complications need further clinical study.